Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | AGXT | P21549 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 3/20 | 0.49 |
| ▸ | PPARA | Q07869 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | CHKA | P35790 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7507938 | 0.95 | SLC2A1 (0.58) | SLC2A1DRD2DRD4DRD3KDM4E | |
| SCHEMBL7502837 | 0.85 | DRD2 (0.76) | SLC2A1DRD2DRD4DRD3KDM4E | |
| SCHEMBL15937919 | 0.85 | HTR7 (0.69) | DRD2DRD3KDM4EPOLBALDH1A1 | |
| SCHEMBL20272705 | 0.84 | HTR1A (0.62) | DRD4KDM4EPOLBALDH1A1GAA | |
| SCHEMBL7498974 | 0.82 | DRD4 (0.72) | DRD2DRD4DRD3HTR7 | |
| SCHEMBL15937936 | 0.81 | DRD4 (0.67) | DRD2DRD4DRD3KDM4EPOLB | |
| SCHEMBL7502997 | 0.81 | SLC2A1 (0.51) | SLC2A1CHRM3 | |
| SCHEMBL7497271 | 0.81 | DRD4 (0.65) | SLC2A1DRD2DRD4DRD3KDM4E | |
| SCHEMBL7991752 | 0.81 | DRD4 (0.79) | DRD2DRD4DRD3KDM4EPOLB | |
| SCHEMBL6863480 | 0.80 | SIGMAR1 (0.67) | DRD4KDM4EPOLBALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931067-B1 | D4 RECEPTOR SELECTIVITY PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2002-06-26 | — | — | EP | disclosed |
| US-6258813-B1 | BIOLOGICAL RECEPTORS WITH TETRAHYDROPIPERIZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT (DE) | 2001-07-10 | — | — | US | disclosed |