Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 1/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987944 | 0.91 | HTR2C (0.38) | ABCC8KCNJ11SLC6A4HTR2CMCL1 | |
| SCHEMBL7974300 | 0.90 | HTR2C (0.37) | SLC6A4HTR2CMCL1CACNA1GCACNA1B | |
| SCHEMBL7985457 | 0.90 | HTR2C (0.46) | SLC6A4HTR2CKMT2AMCL1HPGD | |
| SCHEMBL7988121 | 0.85 | SMN1; SMN2 (0.41) | SLC6A4HTR2CMEN1KMT2AMCL1 | |
| SCHEMBL7975222 | 0.83 | MCL1 (0.39) | SLC6A4HTR2CMCL1LMNAHTR2A | |
| SCHEMBL7988928 | 0.83 | GAA (0.44) | SLC6A4HTR2CMCL1PTGER2HPGD | |
| SCHEMBL7992290 | 0.82 | HPGD (0.42) | ABCC8KCNJ11NR1H4SLC6A4HTR2C | |
| SCHEMBL7988917 | 0.82 | HTR2C (0.40) | SLC6A4HTR2CKMT2AMCL1HPGD | |
| SCHEMBL7984728 | 0.81 | NR1H4 (0.41) | ABCC8KCNJ11NR1H4MEN1RAB9A | |
| SCHEMBL7991605 | 0.81 | HTR2C (0.41) | SLC6A4HTR2CMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |