Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.32 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985478 | 0.91 | PAX8 (0.45) | NR1H4PAX8ALDH1A1 | |
| SCHEMBL7988794 | 0.90 | NR1H4 (0.40) | NR1H4PAX8ABCC8KCNJ11PTGES | |
| SCHEMBL7984727 | 0.83 | HPGD (0.40) | NR1H4PAX8ABCC8KCNJ11KMT2A | |
| SCHEMBL7974156 | 0.82 | BRD4 (0.43) | NR1H4PAX8KAT8ALDH1A1 | |
| SCHEMBL7988522 | 0.81 | NR1H4 (0.44) | NR1H4ABCC8KCNJ11S1PR4S1PR1 | |
| SCHEMBL7992285 | 0.81 | ABCC8 (0.41) | NR1H4ABCC8KCNJ11RAB9AMEN1 | |
| SCHEMBL7987361 | 0.80 | MET (0.45) | NR1H4ABCC8KCNJ11S1PR4S1PR1 | |
| SCHEMBL7974490 | 0.80 | NR1H4 (0.47) | NR1H4ABCC8KCNJ11PTGESALOX5 | |
| SCHEMBL7984932 | 0.79 | ABCC8 (0.43) | NR1H4ABCC8KCNJ11S1PR4S1PR1 | |
| SCHEMBL7984868 | 0.78 | NR1H4 (0.42) | NR1H4ABCC8KCNJ11S1PR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |