Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988121 | 0.89 | SMN1; SMN2 (0.41) | GAAHTR2CSLC6A4YTHDC1MCL1 | |
| SCHEMBL7985457 | 0.88 | HTR2C (0.46) | GAAHTR2CSLC6A4HPGDMCL1 | |
| SCHEMBL7988933 | 0.84 | GAA (0.44) | GAATP53RXFP1HTR2CSLC6A4 | |
| SCHEMBL7987944 | 0.83 | HTR2C (0.38) | TP53HTR2CSLC6A4HPGDMCL1 | |
| SCHEMBL7974300 | 0.83 | HTR2C (0.37) | HTR2CSLC6A4HPGDMCL1 | |
| SCHEMBL7992285 | 0.83 | ABCC8 (0.41) | PTGER2HTR2CSLC6A4HPGDMCL1 | |
| SCHEMBL7975222 | 0.81 | MCL1 (0.39) | TP53HTR2CSLC6A4POLBMCL1 | |
| SCHEMBL7984512 | 0.81 | GAA (0.50) | GAATP53RXFP1PTGER4PTGER2 | |
| SCHEMBL7991605 | 0.81 | HTR2C (0.41) | HTR2CSLC6A4MCL1 | |
| SCHEMBL7984135 | 0.80 | GAA (0.49) | GAATP53RXFP1PTGER4PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |