Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | VHL | P40337 | 1/20 | 0.47 |
| ▸ | ELOC | Q15369 | 1/20 | 0.47 |
| ▸ | ELOB | Q15370 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13135 | 0.82 | KDM4E (0.58) | KDM4EHTTVHLELOCELOB | |
| SCHEMBL30714352 | 0.82 | KDM4E (0.58) | KDM4EHTTVHLELOCELOB | |
| SCHEMBL86216 | 0.82 | VHL (0.54) | KDM4EHTTVHLELOCELOB | |
| SCHEMBL69249 | 0.82 | VHL (0.64) | KDM4EHTTVHLELOCELOB | |
| Ethylene SCHEMBL8101571 | 0.79 | VHL (0.60) | KDM4EHTTVHLELOCELOB | |
| SCHEMBL5203764 | 0.72 | VHL (0.51) | KDM4EHTTVHLELOCELOB | |
| SCHEMBL5956746 | 0.72 | KDM4E (0.47) | KDM4EHTTVHLELOCELOB | |
| SCHEMBL7991966 | 0.72 | MAOB (0.51) | HTTALDH1A1MAPTLMNANPC1 | |
| SCHEMBL29649816 | 0.69 | S100A4 (0.56) | KDM4EALDH1A1CYP2A6MEN1KMT2A | |
| SCHEMBL15210826 | 0.69 | S100A4 (0.56) | KDM4EALDH1A1CYP2A6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211385-B1 | STARTING FROM THIOCHROMAN-4-ONE COMPOUND | ALLERGAN SALES, INC. | 2001-04-03 | — | — | US | disclosed |
| WO-2000068220-A1 | PROCESS FOR PREPARING SUBSTITUTED BENZO[1,2-G]-CHROM-3-ENE, BENZO[1,2-G]-THIOCHROM-3-ENE AND BENZO[1,2-G]-1,2-DIHYDROQUINOLINE DERIVATIVES | ALLERGAN SALES, INC. (US) | 2000-11-16 | — | — | WO | disclosed |
| US-6043381-A | Process for preparing substituted benzo[1,2-g]-chrom-3-ene, benzo[1,2-g]-thiochrom-3-ene and benzo[1,2-g]-1,2-dihydroquinoline derivatives | ALLERGAN SALES, INC. (US) | 2000-03-28 | — | — | US | disclosed |