Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991209 | 0.94 | KDM4E (0.33) | ALDH1A1ALOX15KDM4ETDP1 | |
| SCHEMBL7991206 | 0.94 | KDM4E (0.33) | ALDH1A1ALOX15KDM4ETDP1 | |
| SCHEMBL7994439 | 0.88 | CYP1A2 (0.30) | — | |
| SCHEMBL7479466 | 0.86 | — | — | |
| SCHEMBL7998008 | 0.84 | — | — | |
| SCHEMBL7998012 | 0.84 | — | — | |
| SCHEMBL7980424 | 0.82 | — | — | |
| SCHEMBL7992356 | 0.82 | CYP1A2 (0.33) | — | |
| SCHEMBL7992364 | 0.82 | CYP1A2 (0.33) | — | |
| Magnesium Chloride Anhydrous SCHEMBL28459445 | 0.79 | ALDH1A1 (0.33) | ALDH1A1ALOX15KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3638686-B1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2021-10-27 | — | — | EP | disclosed |
| US-10927146-B2 | Peptidyl ketoamides as inhibitors of rhomboid proteases | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2021-02-23 | — | — | US | disclosed |
| EP-3638686-A1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | Ústav Organické Chemie A Biochemie Akademie Ved Ceské Republiky, v.v.i. (CZ) | 2020-04-22 | — | — | EP | disclosed |
| US-20200095278-A1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2020-03-26 | — | — | US | disclosed |
| WO-2018228617-A1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. (CZ) | 2018-12-20 | — | — | WO | disclosed |
| US-6277790-B1 | APPLYING PLANTS, SEEDS, SOILS OR ENVIRONMENT | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-21 | — | — | US | disclosed |
| US-4698231-A | Sweetening with L-aminodicarboxylic acid amides | GENERAL FOOD CORPORATION (US) | 1987-10-06 | — | — | US | disclosed |
| US-4678674-A | Sweetening with L-aminodicarboxylic acid amides | GENERAL FOODS CORPORATION (US) | 1987-07-07 | — | — | US | disclosed |
| US-4676989-A | Sweetening with cycloalkyl ethers and thioethers of dipeptides | GENERAL FOODS CORPORATION (US) | 1987-06-30 | — | — | US | disclosed |
| US-4654219-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1987-03-31 | — | — | US | disclosed |
| US-4638071-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1987-01-20 | — | — | US | disclosed |
| US-4636396-A | Foodstuff with L-aminodicarboxylic acid gem-diamines | GENERAL FOODS CORPORATION (US) | 1987-01-13 | — | — | US | disclosed |
| US-4622417-A | DIETETICS | GENERAL FOODS CORPORATION (US) | 1986-11-11 | — | — | US | disclosed |
| US-4622418-A | LOW CALORIE SWEETENERS | GENERAL FOODS CORPORATION (US) | 1986-11-11 | — | — | US | disclosed |
| EP-0199258-A2 | L-Aminodicarboxylic acid amides and an edible composition containing same | GENERAL FOODS CORPORATION (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4619782-A | L-aminodicarboxylic acid gem-diamines | GENERAL FOODS CORPORATION (US) | 1986-10-28 | — | — | US | disclosed |
| EP-0186173-A2 | L-Aminodicarboxylic-(0-cycloalkyl)-L-aminocarboxylate alkyl esters, an edible composition containing same as sweeteners and a method for sweetening an edible composition | GENERAL FOODS CORPORATION (US) | 1986-07-02 | — | — | EP | disclosed |
| US-4572799-A | L-Aminodicarboxylic acid amides | GENERAL FOODS CORPORATION (US) | 1986-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927146-B2 | Peptidyl ketoamides as inhibitors of rhomboid proteases | PARL, TMPRSS15, RNASE1 | ALDH1A1 4168/4885ALOX15 240/4885KDM4E 1236/4885 |
| US-20200095278-A1 | PEPTIDYL KETOAMIDES AS INHIBITORS OF ROHOMBOID PROTEASES | RNASE1, TMPRSS15, SPINT2 | ALDH1A1 3485/4885ALOX15 206/4885KDM4E 1358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.