SCHEMBL7993122

SCHEMBL7993122

Cn1c(-c2ccc(N)cc2F)nnc1C(C)(C)Oc1c(F)cc(F)cc1F

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 4/20 0.36
KIT P10721 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12677397 0.93 HSD11B1 (0.36) HSD11B1KIT
SCHEMBL7985976 0.91 HSD11B1 (0.38) HSD11B1KIT
SCHEMBL12671096 0.90 HSD11B1 (0.40) HSD11B1
SCHEMBL7981154 0.88 HSD11B1 (0.36) HSD11B1KIT
SCHEMBL7981353 0.86 KIT (0.31) KIT
SCHEMBL7982385 0.86 KIT (0.31) KIT
SCHEMBL12677300 0.86 MAPK14 (0.36) HSD11B1KIT
SCHEMBL12671044 0.85 NSD2 (0.34) HSD11B1
SCHEMBL7981848 0.85 ALDH1A1 (0.33) KIT
SCHEMBL12671092 0.84 HSD11B1 (0.46) HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010001946-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF アステラス製薬株式会社 (JP) 2010-01-07 WO disclosed