SCHEMBL7993247

SCHEMBL7993247

COc1cc(OC)c(C(=O)Nc2cccc3c2CCN(C)C3C)cc1Br

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.43
LMNA P02545 4/20 0.43
ALDH1A1 P00352 4/20 0.43
MAPT P10636 4/20 0.43
HTT P42858 1/20 0.43
RXFP1 Q9HBX9 1/20 0.41
KMT2A Q03164 5/20 0.41
MEN1 O00255 4/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MAPK1 P28482 2/20 0.41
USP2 O75604 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
NPSR1 Q6W5P4 3/20 0.41
POLB P06746 2/20 0.41
CYP1A2 P05177 2/20 0.39
CYP3A4 P08684 2/20 0.39
HPGD P15428 2/20 0.39
HSD17B10 Q99714 2/20 0.39
CYP2C9 P11712 1/20 0.39
NPC1 O15118 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7993464 0.83 KMT2A (0.42) KDM4ELMNAALDH1A1MAPTKMT2A
SCHEMBL7991365 0.83 BRPF1 (0.43) KDM4ELMNAALDH1A1MAPTKMT2A
SCHEMBL7993333 0.82 NR1H4 (0.45) KDM4ELMNAALDH1A1MAPTHTT
SCHEMBL7979061 0.82 PDE4D (0.39) KDM4ELMNAALDH1A1RXFP1KMT2A
SCHEMBL8184618 0.81 KMT2A (0.46) KDM4ELMNAALDH1A1MAPTHTT
SCHEMBL7792077 0.77 MEN1 (0.44) KDM4ELMNAALDH1A1MAPTHTT
SCHEMBL7990102 0.76 NR1H4 (0.46) KDM4ELMNAALDH1A1MAPTRXFP1
SCHEMBL8012751 0.75 ADRA2A (0.46) ALDH1A1POLBHPGDNPC1RAB9A
SCHEMBL7797970 0.74 KMT2A (0.42) KDM4ELMNAMAPTKMT2AMEN1
SCHEMBL8176110 0.74 MAP3K5 (0.43) KDM4EMAPTRXFP1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6277861-B1 FOR TREATMENT AND PROPHYLAXIS OF NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS, MUSCULAR DISORDERS, DRUG ADDICTION WITHDRAWAL, PAIN SMITHKLINE BEECHAM, P.L.C. (GB) 2001-08-21 US claimed
EP-0971897-A1 ANTI-CONVULSANT ISOQUINOLYL-BENZAMIDE DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2000-01-19 EP claimed
WO-1998041507-A1 ANTI-CONVULSANT ISOQUINOLYL-BENZAMIDE DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 1998-09-24 WO claimed
US-6277861-B1 FOR TREATMENT AND PROPHYLAXIS OF NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS, MUSCULAR DISORDERS, DRUG ADDICTION WITHDRAWAL, PAIN SMITHKLINE BEECHAM, P.L.C. (GB) 2001-08-21 US disclosed
CN-1255917-A Anti-convulsant isoquinolyl-benzamide derivatives SMITHKLINE BEECHAM PLC (GB) 2000-06-07 CN disclosed
EP-0971897-A1 ANTI-CONVULSANT ISOQUINOLYL-BENZAMIDE DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2000-01-19 EP disclosed
WO-1998041507-A1 ANTI-CONVULSANT ISOQUINOLYL-BENZAMIDE DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 1998-09-24 WO disclosed