Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964058 | 0.86 | ALDH1A1 (0.42) | MAPK1HTTALDH1A1LMNAMAPT | |
| SCHEMBL28380438 | 0.84 | NPSR1 (0.41) | NPSR1ACHEMAPK1DRD2DRD4 | |
| SCHEMBL25386742 | 0.81 | HCRTR1 (0.54) | ACHEMAPK1GAALMNAMAPT | |
| SCHEMBL30567223 | 0.81 | HCRTR1 (0.54) | ACHEMAPK1GAALMNAMAPT | |
| SCHEMBL28470357 | 0.80 | MAOB (0.45) | MAPK1HTTALDH1A1GAALMNA | |
| SCHEMBL29739285 | 0.80 | MAOB (0.45) | MAPK1HTTALDH1A1GAALMNA | |
| SCHEMBL251644 | 0.79 | ALDH1A1 (0.43) | MAPK1ALDH1A1LMNAMAPTCYP3A4 | |
| SCHEMBL4068582 | 0.78 | HPGD (0.52) | ACHEMAPK1DRD2DRD4HTT | |
| SCHEMBL6510351 | 0.78 | HPGD (0.52) | NPSR1ACHEDRD2DRD4HTT | |
| SCHEMBL9052820 | 0.77 | ACHE (0.60) | ACHEMAPK1DRD2DRD4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5631280-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996030014-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |