Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 20/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 20/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593876 | 0.78 | SLC6A4 (0.50) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL27387398 | 0.67 | SLC6A4 (0.36) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL7806789 | 0.64 | SLC6A3 (0.44) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL4591524 | 0.63 | SLC6A3 (0.42) | SLC6A4SLC6A3SLC6A2CYP2D6CYP3A4 | |
| SCHEMBL27422400 | 0.63 | SIGMAR1 (0.46) | SLC6A4 | |
| SCHEMBL7385128 | 0.63 | SLC6A3 (0.47) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL9863742 | 0.63 | SLC6A4 (0.69) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL30580699 | 0.62 | HSD11B1 (0.37) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL27422407 | 0.62 | SIGMAR1 (0.45) | SLC6A4 | |
| SCHEMBL9864269 | 0.62 | SLC6A4 (0.53) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288079-B1 | MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS; NERVOUS SYSTEM, PSYCHOLOGICAL, EATING, SLEEP, AND BRAIN DISORDERS; ALZHEIMER*S AND PARKINSON*S DISEASE; TESOFENSINE (2-ethoxymethyl-3-(3,4-dichlorophenyl)-tropane) | NEUROSEARCH A/S (DK) | 2001-09-11 | — | — | US | disclosed |