Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27545657 | 0.86 | HDAC4 (0.42) | NR1H2HDAC4HDAC2HDAC8HDAC6 | |
| Biphenyl SCHEMBL4649459 | 0.83 | KMT2A (0.44) | NR1H2PTGS2MAPTKDM4EALDH1A1 | |
| SCHEMBL28902435 | 0.81 | NR1H2 (0.46) | NR1H2HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL31229117 | 0.78 | CASP3 (0.48) | MAPTKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL8452187 | 0.78 | CASP3 (0.48) | MAPTKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL24736915 | 0.72 | HDAC4 (0.52) | HDAC4HDAC2HDAC8HDAC6PTGS2 | |
| SCHEMBL11424452 | 0.72 | HDAC4 (0.52) | HDAC4HDAC2HDAC8HDAC6PABPC1 | |
| SCHEMBL22187708 | 0.72 | MEN1 (0.52) | HDAC4HDAC2HDAC8HDAC6PABPC1 | |
| SCHEMBL29976182 | 0.72 | HDAC4 (0.52) | HDAC4HDAC2HDAC8HDAC6PTGS2 | |
| SCHEMBL29763759 | 0.71 | HNF4A (0.44) | NR1H2HDAC4HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277905-B1 | BLENDING POLYCYCLOHEXYLENEDIMETHYLENE TEREPHTHALATE, RUBBER IMPACT MODIFIER, HALOGENATED ORGANIC COMPOUND CONTAINING AT LEAST ONE IMIDE GROUP AND HAVING SPECIFIED MELTING POINT, REINFORCING FIBER AND SELECTED PHOSPHITE | EASTMAN CHEMICAL COMPANY | 2001-08-21 | — | — | US | disclosed |