Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | CDK9 | P50750 | 4/20 | 0.37 |
| ▸ | CDK7 | P50613 | 2/20 | 0.37 |
| ▸ | CCNH | P51946 | 2/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 6/20 | 0.36 |
| ▸ | CCNK | O75909 | 4/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 3/20 | 0.33 |
| ▸ | NOS2 | P35228 | 3/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7505916 | 0.91 | CCNT1 (0.38) | CCNT1CCNE1CDK2CDK9CDK7 | |
| SCHEMBL7986838 | 0.91 | CCNT1 (0.40) | CCNT1CCNE1CDK2CDK9CDK7 | |
| SCHEMBL7975983 | 0.91 | CCNT1 (0.36) | CCNT1CCNE1CDK2CDK9CDK7 | |
| SCHEMBL7990500 | 0.90 | KDM1A (0.41) | CCNT1CDK9KDM1AXDHCHRNB1 | |
| SCHEMBL7993904 | 0.87 | KDR (0.38) | CDK2KDM1A | |
| SCHEMBL7990169 | 0.86 | PDE4B (0.37) | CCNT1CCNE1CDK2CDK9CDK7 | |
| SCHEMBL7987305 | 0.86 | CCNT1 (0.42) | CCNT1CCNE1CDK2CDK9CDK7 | |
| SCHEMBL7987644 | 0.86 | CCNT1 (0.40) | CCNT1CCNE1CDK2CDK9CDK7 | |
| SCHEMBL7976151 | 0.85 | CCNT1 (0.37) | CCNT1CCNE1CDK2CDK9CDK7 | |
| SCHEMBL7990463 | 0.85 | CHEK1 (0.39) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |