Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.51 |
| ▸ | HRH2 | P25021 | 4/20 | 0.51 |
| ▸ | HRH1 | P35367 | 4/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7985957 | 0.87 | RAB9A (0.53) | HRH3HRH2HRH1LTA4HMEN1 | |
| SCHEMBL7985189 | 0.84 | HRH3 (0.57) | HRH3LTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL7922904 | 0.81 | LTA4H (0.58) | HRH3HRH2HRH1LTA4HMEN1 | |
| SCHEMBL13108426 | 0.81 | HRH3 (0.43) | HRH3HRH2HRH1LTA4HMEN1 | |
| SCHEMBL7998333 | 0.78 | LTA4H (0.43) | HRH3HRH2HRH1LTA4HALDH1A1 | |
| SCHEMBL20029250 | 0.74 | UGCG (0.44) | MEN1CYP2D6KMT2A | |
| SCHEMBL19287586 | 0.73 | HRH3 (0.37) | HRH3HRH2HRH1LTA4HMEN1 | |
| SCHEMBL17937331 | 0.73 | MEN1 (0.45) | LTA4HMEN1ALDH1A1KMT2A | |
| SCHEMBL5544810 | 0.72 | LTA4H (0.69) | HRH3HRH2HRH1LTA4HALDH1A1 | |
| SCHEMBL13980797 | 0.71 | LTA4H (0.67) | HRH3HRH2HRH1LTA4HMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2009117150-A2 | METHOD OF TREATING LUPUS WITH CERAMIDE DERIVATIVES | GENZYME CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |