Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 8/20 | 0.46 |
| ▸ | HTR2A known ✓ | P28223 | 7/20 | 0.42 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.41 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7994532 | 1.00 | HTR2C (0.46) | HTR2CHTR2ADYRK1ACNR1HTR2B | |
| SCHEMBL7995774 | 0.89 | HTR2C (0.56) | HTR2CHTR2AHTR2B | |
| SCHEMBL7983641 | 0.81 | HTR2C (0.63) | HTR2CHTR2AHTR2B | |
| SCHEMBL7983649 | 0.81 | HTR2C (0.63) | HTR2CHTR2AHTR2B | |
| Fumaric Acid SCHEMBL7088510 | 0.79 | HTR2C (0.64) | HTR2CHTR2AHTR2BHDAC1HDAC2 | |
| Fumaric Acid SCHEMBL7088508 | 0.79 | HTR2C (0.64) | HTR2CHTR2AHTR2BHDAC1HDAC2 | |
| Fumaric Acid SCHEMBL6364123 | 0.79 | HTR2C (0.48) | HTR2CHTR2ADYRK1AHTR2BPLA2G10 | |
| Fumaric Acid SCHEMBL5678109 | 0.79 | HTR2C (0.48) | HTR2CHTR2ADYRK1AHTR2BPLA2G10 | |
| Fumaric Acid SCHEMBL6364117 | 0.79 | HTR2C (0.48) | HTR2CHTR2ADYRK1AHTR2BPLA2G10 | |
| Fumaric Acid SCHEMBL5678095 | 0.79 | HTR2C (0.48) | HTR2CHTR2ADYRK1AHTR2BPLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001040183-A1 | 1-AMINOALKYL-1H-INDOLES FOR TREATING GLAUCOMA | ALCON UNIVERSAL LTD. (CH) | 2001-06-07 | — | — | WO | disclosed |