Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 6/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.37 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.35 |
| ▸ | KAT7 | O95251 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994227 | 0.93 | CDK9 (0.39) | CHEK1SLC6A3CDK9CCNT1CCNE1 | |
| SCHEMBL7506739 | 0.92 | CDK7 (0.39) | CHEK1SLC6A3CDK9CCNT1CCNE1 | |
| SCHEMBL7986731 | 0.91 | CHEK1 (0.41) | CHEK1 | |
| SCHEMBL7511168 | 0.89 | CHEK1 (0.40) | CHEK1CDK9CCNT1CCNE1CDK2 | |
| SCHEMBL7508016 | 0.87 | OPRK1 (0.42) | CHEK1CDK9CCNT1CCNE1CDK2 | |
| SCHEMBL7976643 | 0.86 | CDK9 (0.40) | CHEK1SLC6A3CDK9CCNT1CCNE1 | |
| SCHEMBL7991127 | 0.82 | CDK7 (0.46) | CHEK1CDK9CCNT1CCNE1CDK2 | |
| SCHEMBL7986848 | 0.81 | CCNT1 (0.38) | CHEK1SLC6A3CDK9CCNT1CCNE1 | |
| SCHEMBL7503926 | 0.81 | CCNT1 (0.38) | CHEK1SLC6A3CDK9CCNT1CCNE1 | |
| SCHEMBL7990422 | 0.80 | ABL1 (0.38) | CHEK1SLC6A3CDK9CCNT1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |