Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511168 | 0.93 | CHEK1 (0.40) | CHEK1GRIN1GRIN2BTYRO3CCNC | |
| SCHEMBL7506739 | 0.92 | CDK7 (0.39) | CHEK1AXLF10 | |
| SCHEMBL7994754 | 0.91 | CHEK1 (0.38) | CHEK1 | |
| SCHEMBL7994227 | 0.89 | CDK9 (0.39) | CHEK1CCNCCDK8 | |
| SCHEMBL7508016 | 0.87 | OPRK1 (0.42) | CHEK1ITGB3ITGA2BAXL | |
| SCHEMBL7990422 | 0.87 | ABL1 (0.38) | CHEK1ABL1EGFRSRCABL2 | |
| SCHEMBL7976272 | 0.84 | CCNT1 (0.41) | CHEK1ABL1EGFRSRCABL2 | |
| SCHEMBL7975970 | 0.82 | HTR6 (0.39) | CHEK1TYRO3ABL1EGFRSRC | |
| SCHEMBL7994923 | 0.80 | PRKCA (0.40) | CHEK1TYRO3ABL1EGFRSRC | |
| SCHEMBL7990984 | 0.80 | CCNT1 (0.36) | CHEK1TYRO3ABL1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |