Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | ABL2 | P42684 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976189 | 0.93 | CCNT1 (0.40) | EGFRSRCCCNT1CCNE1CDK2 | |
| SCHEMBL7976643 | 0.90 | CDK9 (0.40) | CCNT1CCNE1CDK2CDK7CDK9 | |
| SCHEMBL7990707 | 0.90 | CDK9 (0.44) | CCNT1CCNE1CDK2CDK7CDK9 | |
| SCHEMBL7976272 | 0.87 | CCNT1 (0.41) | ABL1EGFRSRCABL2CCNT1 | |
| SCHEMBL7990432 | 0.87 | CDK9 (0.42) | CCNT1CCNE1CDK2CDK7CDK9 | |
| SCHEMBL7986731 | 0.87 | CHEK1 (0.41) | ABL1EGFRSRCABL2CYP2C19 | |
| SCHEMBL7994923 | 0.86 | PRKCA (0.40) | ABL1EGFRSRCABL2CCNT1 | |
| SCHEMBL7990984 | 0.86 | CCNT1 (0.36) | ABL1EGFRSRCABL2CCNT1 | |
| SCHEMBL7975970 | 0.86 | HTR6 (0.39) | ABL1EGFRSRCABL2CYP2C19 | |
| SCHEMBL7993811 | 0.84 | KDR (0.39) | CCNT1CCNE1CDK2CDK7CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |