Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | CDK4 | P11802 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | CCND1 | P24385 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31697960 | 1.00 | ALDH1A1 (0.70) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL30532191 | 0.84 | ALDH1A1 (0.78) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL14059746 | 0.84 | ALDH1A1 (0.78) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL7940135 | 0.83 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL12377760 | 0.83 | ALDH1A1 (0.76) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL30672960 | 0.81 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL5636449 | 0.81 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL29875634 | 0.80 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| SCHEMBL29558 | 0.80 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2AUSP2CDK4 | |
| Hydrochloric Acid SCHEMBL7255401 | 0.80 | ALDH1A1 (0.70) | ALDH1A1MEN1KMT2AUSP2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776378-A | Preparation method of polychlorinated methyl indoline without metal catalyst | 哈尔滨商业大学 | 2019-05-21 | — | — | CN | claimed |
| CN-111995561-B | High-yield preparation method of polychloro-methylindoline without metal catalyst | 哈尔滨商业大学 | 2023-07-04 | — | — | CN | disclosed |
| CN-109776378-A | Preparation method of polychlorinated methyl indoline without metal catalyst | 哈尔滨商业大学 | 2019-05-21 | — | — | CN | disclosed |
| CN-109776378-A | Preparation method of polychlorinated methyl indoline without metal catalyst | 哈尔滨商业大学 | 2019-05-21 | — | — | CN | disclosed |
| CN-109776378-A | Preparation method of polychlorinated methyl indoline without metal catalyst | 哈尔滨商业大学 | 2019-05-21 | — | — | CN | disclosed |
| CN-106831801-B | Method for preparing spirooxindole lactone compound by NHC catalysis | 南京工业大学 | 2019-03-15 | — | — | CN | disclosed |
| US-9969685-B2 | Enantioselective synthesis of pyrroloindole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-15 | — | — | US | disclosed |
| WO-2018064094-A1 | ENANTIOSELECTIVE SYNTHESIS OF PYRROLOINDOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-05 | — | — | WO | disclosed |
| US-20180086701-A1 | ENANTIOSELECTIVE SYNTHESIS OF PYRROLOINDOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY | 2018-03-29 | — | — | US | disclosed |
| CN-106831801-A | Method for preparing spirooxindole lactone compound by NHC catalysis | 南京工业大学 | 2017-06-13 | — | — | CN | disclosed |
| WO-2001083482-A1 | DNA ALKYLATING AGENT AND ACTIVATION THEREOF | THE SCRIPPS RESEARCH INSTITUTE (US) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086701-A1 | ENANTIOSELECTIVE SYNTHESIS OF PYRROLOINDOLE COMPOUNDS | PCNA, POLR2E, POLL | ALDH1A1 2929/4885MEN1 3599/4885KMT2A 2283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.