Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1514871 | 0.82 | SIGMAR1 (0.50) | ALDH1A1SIGMAR1HRH3POLBMEN1 | |
| SCHEMBL6731660 | 0.77 | ALDH1A1 (0.42) | ALDH1A1KDM4EHRH3SMN1; SMN2NPC1 | |
| SCHEMBL688048 | 0.76 | SIGMAR1 (0.48) | ALDH1A1SIGMAR1HRH3NPC1POLB | |
| SCHEMBL2208144 | 0.73 | HRH3 (0.46) | ALDH1A1KDM4ELSSHRH3HPGD | |
| SCHEMBL23851111 | 0.70 | ALDH1A1 (0.87) | ALDH1A1KDM4ESIGMAR1LSSHRH3 | |
| SCHEMBL12220145 | 0.70 | KDM4E (0.48) | ALDH1A1KDM4ESIGMAR1LSSSMN1; SMN2 | |
| SCHEMBL7937990 | 0.70 | ALDH1A1 (0.95) | ALDH1A1KDM4ESIGMAR1LSSHRH3 | |
| SCHEMBL10696872 | 0.69 | ALDH1A1 (0.63) | ALDH1A1KDM4ESIGMAR1LSSHRH3 | |
| Hydrochloric Acid SCHEMBL2533088 | 0.68 | ALDH1A1 (0.47) | ALDH1A1KDM4ESIGMAR1LSSSMN1; SMN2 | |
| SCHEMBL1276590 | 0.68 | ALDH1A1 (1.00) | ALDH1A1KDM4ESIGMAR1HRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001051494-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-07-19 | — | — | WO | disclosed |