Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996147 | 0.94 | LMNA (0.42) | LMNASMN1; SMN2KDM4EPKMHTT | |
| SCHEMBL7996075 | 0.92 | F10 (0.48) | LMNASMN1; SMN2PKMHTTTP53 | |
| SCHEMBL7997639 | 0.91 | L3MBTL1 (0.45) | LMNASMN1; SMN2PKMTP53ALDH1A1 | |
| SCHEMBL7997760 | 0.91 | MAPT (0.47) | LMNASMN1; SMN2KDM4EPKMHTT | |
| SCHEMBL8003134 | 0.91 | MAPT (0.48) | LMNASMN1; SMN2KDM4EPKMTP53 | |
| SCHEMBL7999821 | 0.89 | F10 (0.48) | LMNASMN1; SMN2PKMHTTTP53 | |
| SCHEMBL7996216 | 0.89 | LMNA (0.46) | LMNASMN1; SMN2KDM4ETP53ALDH1A1 | |
| SCHEMBL7986759 | 0.88 | MAPT (0.42) | LMNASMN1; SMN2PKMTP53ALDH1A1 | |
| SCHEMBL7999738 | 0.86 | F10 (0.47) | LMNASMN1; SMN2TP53MAPTF10 | |
| SCHEMBL7074071 | 0.86 | KDM4E (0.56) | LMNASMN1; SMN2KDM4EPKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008005-A2 | PIPERAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-02-17 | — | — | WO | disclosed |