SCHEMBL7996560

SCHEMBL7996560

Cc1cc(C)nc(NC23CC4CC(CC(C4)C2)C3)n1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.57
TSHR P16473 2/20 0.57
LMNA P02545 2/20 0.57
ALDH1A1 P00352 1/20 0.57
MAPT P10636 2/20 0.52
NPC1 O15118 1/20 0.52
MAPK1 P28482 1/20 0.52
RAB9A P51151 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
GAA P10253 3/20 0.50
POLB P06746 2/20 0.50
TP53 P04637 1/20 0.50
HTT P42858 1/20 0.50
HSD17B10 Q99714 1/20 0.50
HDAC3 O15379 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
EPHX2 P34913 3/20 0.42
ADORA3 P0DMS8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7994986 0.89 L3MBTL1 (0.50) L3MBTL1TSHRLMNAALDH1A1MAPT
SCHEMBL7994849 0.80 EPHX2 (0.50) L3MBTL1TSHRLMNAALDH1A1MAPT
Hydrochloric Acid SCHEMBL7984877 0.78 EPHX2 (0.49) L3MBTL1TSHRLMNAALDH1A1MAPT
SCHEMBL9084932 0.78 TSHR (0.53) L3MBTL1TSHRLMNAALDH1A1MAPT
SCHEMBL7966600 0.77 NOS3 (0.47) L3MBTL1TSHRLMNAALDH1A1MAPT
SCHEMBL7994913 0.77 L3MBTL1 (0.43) L3MBTL1TSHRLMNAALDH1A1MAPT
Acetone SCHEMBL9090087 0.74 TSHR (0.49) L3MBTL1TSHRLMNAALDH1A1MAPT
SCHEMBL10064723 0.73 TSHR (0.56) L3MBTL1TSHRLMNAALDH1A1MAPT
SCHEMBL12044178 0.73 TSHR (1.00) L3MBTL1TSHRLMNAALDH1A1MAPT
SCHEMBL9085242 0.73 TSHR (0.47) L3MBTL1TSHRLMNAALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001074789-A1 NEW (1-ADAMANTYLAMINO)PYRIMIDINES AND METHOD OF THEIR PREPARATION FUNDACJA ROZWOJU DIAGNOSTYKI I TERAPII (PL) 2001-10-11 WO claimed
WO-2001074789-A1 NEW (1-ADAMANTYLAMINO)PYRIMIDINES AND METHOD OF THEIR PREPARATION FUNDACJA ROZWOJU DIAGNOSTYKI I TERAPII (PL) 2001-10-11 WO disclosed