Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050776 | 0.71 | TYR (0.39) | TYRALOX15MEN1TP53CYP3A4 | |
| SCHEMBL6050795 | 0.71 | ALOX5 (0.42) | TYRALOX15MEN1TP53CYP3A4 | |
| SCHEMBL29093329 | 0.70 | LMNA (0.33) | LMNAMAPK1 | |
| SCHEMBL19927819 | 0.67 | ALOX5 (0.41) | TYRALOX15MEN1TP53CYP3A4 | |
| SCHEMBL16405011 | 0.67 | ALOX5 (0.41) | TYRALOX15MEN1TP53CYP3A4 | |
| SCHEMBL14099994 | 0.67 | ALOX5 (0.45) | TYRALOX15MEN1TP53CYP3A4 | |
| SCHEMBL2689105 | 0.67 | ALOX15 (0.41) | TYRALOX15MEN1TP53CYP3A4 | |
| SCHEMBL2688868 | 0.67 | ALOX15 (0.38) | TYRALOX15MEN1TP53CYP3A4 | |
| SCHEMBL2689599 | 0.67 | ALOX15 (0.41) | TYRALOX15MEN1TP53CYP3A4 | |
| SCHEMBL2691198 | 0.67 | ALOX15 (0.38) | TYRALOX15MEN1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000009613-A2 | NEW CLASS OF HIGH HYPERPOLARIZABILITY ORGANIC CHROMOPHORES AND PROCESS FOR SYNTHESIZING THE SAME | PACIFIC WAVE INDUSTRIES, INC. (US) | 2000-02-24 | — | — | WO | disclosed |