Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 10/20 | 0.47 |
| ▸ | DRD4 | P21917 | 10/20 | 0.47 |
| ▸ | DRD3 | P35462 | 9/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979110 | 0.91 | DRD4 (0.46) | DRD2DRD4DRD3ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL7991375 | 0.91 | DRD4 (0.45) | DRD2DRD4DRD3HTR1AADRA1D | |
| SCHEMBL7993833 | 0.88 | LMNA (0.41) | DRD2DRD4DRD3GAAMAPT | |
| Bromide SCHEMBL7991351 | 0.88 | LMNA (0.41) | DRD2DRD4DRD3GAAMAPT | |
| SCHEMBL7997014 | 0.87 | HTR7 (0.44) | PTK2DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL7979506 | 0.86 | ABCB1 (0.52) | DRD2DRD4DRD3GAAHTR1A | |
| Bromide SCHEMBL8218997 | 0.86 | HTR7 (0.43) | PTK2DRD2DRD4DRD3ALDH1A1 | |
| Bromide SCHEMBL7993380 | 0.86 | ABCB1 (0.51) | DRD2DRD4DRD3GAAHTR1A | |
| SCHEMBL7990254 | 0.85 | KDM4E (0.41) | GAAMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL7991687 | 0.84 | DRD2 (0.43) | DRD2DRD4DRD3GAAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288230-B1 | COMPOUNDS FOR TREATMENT OF PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2001-09-11 | — | — | US | claimed |
| US-6288230-B1 | COMPOUNDS FOR TREATMENT OF PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2001-09-11 | — | — | US | disclosed |
| WO-2000018763-A2 | 2-(2,3-DIHYDROBENZOFURAN-5-YL)-4-AMINOMETHYLIMIDAZOLES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 2000-04-06 | — | — | WO | disclosed |