Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | DHPS | P49366 | 16/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997029 | 0.91 | EDNRA (0.49) | EDNRBEDNRADHPSALDH1A1KDM4E | |
| SCHEMBL7996807 | 0.87 | DHPS (0.53) | EDNRBEDNRADHPS | |
| SCHEMBL7993553 | 0.87 | DHPS (0.50) | EDNRBEDNRADHPS | |
| SCHEMBL7997005 | 0.84 | EDNRA (0.52) | EDNRADHPS | |
| SCHEMBL7993994 | 0.83 | EDNRB (0.56) | EDNRBEDNRADHPS | |
| SCHEMBL5032708 | 0.83 | DHPS (0.53) | DHPS | |
| SCHEMBL7993871 | 0.82 | EDNRB (0.56) | EDNRBEDNRADHPS | |
| SCHEMBL7997032 | 0.82 | EDNRB (0.59) | EDNRBEDNRADHPS | |
| SCHEMBL6584039 | 0.82 | DHPS (0.69) | EDNRBEDNRADHPS | |
| SCHEMBL7993551 | 0.78 | EDNRA (0.49) | EDNRBEDNRADHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |