Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003154 | 0.91 | HCRTR1 (0.47) | MAPTPOLBTSHRKDM4ECASP1 | |
| SCHEMBL7997760 | 0.89 | MAPT (0.47) | MAPTPOLBP2RX3TSHRKDM4E | |
| SCHEMBL7999733 | 0.88 | MAPT (0.44) | MAPTPOLBP2RX3KDM4EHSD17B10 | |
| SCHEMBL8003134 | 0.87 | MAPT (0.48) | MAPTPOLBP2RX3TSHRKDM4E | |
| SCHEMBL7999952 | 0.87 | LMNA (0.43) | MAPTKDM4EMEN1KMT2AATM | |
| SCHEMBL7070554 | 0.86 | MAPT (0.52) | MAPTPOLBTSHRKDM4ECASP1 | |
| SCHEMBL7986948 | 0.80 | GRM5 (0.45) | MAPTPOLBMEN1KMT2ALMNA | |
| SCHEMBL7997641 | 0.79 | F10 (0.58) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL8000061 | 0.79 | HCRTR1 (0.43) | MAPTPOLBTSHRKDM4ELMNA | |
| SCHEMBL7996072 | 0.79 | LMNA (0.46) | MAPTPOLBKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008005-A2 | PIPERAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-02-17 | — | — | WO | disclosed |