Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 7/20 | 0.40 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986948 | 0.92 | GRM5 (0.45) | MAPTLMNAGRM5TP53MEN1 | |
| SCHEMBL7996075 | 0.88 | F10 (0.48) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL7999952 | 0.88 | LMNA (0.43) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL7997616 | 0.88 | MAPT (0.45) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL7076926 | 0.85 | LSS (0.52) | MAPTLMNATP53KDM4EALDH1A1 | |
| SCHEMBL7999821 | 0.84 | F10 (0.48) | MAPTLMNAGRM5TP53ALDH1A1 | |
| SCHEMBL7999738 | 0.81 | F10 (0.47) | MAPTLMNAGRM5TP53POLB | |
| SCHEMBL8003154 | 0.80 | HCRTR1 (0.47) | MAPTCA2CA9LMNATP53 | |
| SCHEMBL7996072 | 0.80 | LMNA (0.46) | MAPTCA12CA1CA2CA9 | |
| SCHEMBL8000092 | 0.79 | MAPT (0.42) | MAPTCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008005-A2 | PIPERAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-02-17 | — | — | WO | disclosed |