Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999733 | 0.88 | MAPT (0.44) | LMNAKDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL7997616 | 0.87 | MAPT (0.45) | LMNAKDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL7996072 | 0.85 | LMNA (0.46) | LMNAKDM4ESMN1; SMN2CA12CA1 | |
| SCHEMBL7986948 | 0.82 | GRM5 (0.45) | LMNAMAPTTP53MEN1KMT2A | |
| SCHEMBL7074071 | 0.82 | KDM4E (0.56) | LMNAKDM4ESMN1; SMN2MAPTPKM | |
| SCHEMBL8003154 | 0.80 | HCRTR1 (0.47) | LMNAKDM4ECA2CA9MAPT | |
| SCHEMBL7996147 | 0.79 | LMNA (0.42) | LMNAKDM4ESMN1; SMN2MAPTTP53 | |
| SCHEMBL7996075 | 0.77 | F10 (0.48) | LMNASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL7997760 | 0.76 | MAPT (0.47) | LMNAKDM4ESMN1; SMN2MAPTTP53 | |
| SCHEMBL8003134 | 0.76 | MAPT (0.48) | LMNAKDM4ESMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008005-A2 | PIPERAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-02-17 | — | — | WO | disclosed |