SCHEMBL7998675

SCHEMBL7998675

CON(C)C(=O)CCc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 9/20 0.65
FFAR4 Q5NUL3 5/20 0.65
LTB4R Q15722 1/20 0.61
LTB4R2 Q9NPC1 1/20 0.61
ALOX5 P09917 5/20 0.60
EGFR P00533 2/20 0.53
PTGS1 P23219 1/20 0.52
PTGS2 P35354 1/20 0.52
AKR1B1 P15121 1/20 0.52
MAOB P27338 1/20 0.51
LTA4H P09960 1/20 0.51
EPHX2 P34913 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1727025 0.87 KMT2A (0.62) FFAR1ALOX5
SCHEMBL5880810 0.87 CYP2D6 (0.60) FFAR1FFAR4LTB4RLTB4R2MAOB
SCHEMBL2353230 0.86 ALOX5 (0.76) FFAR1FFAR4LTB4RLTB4R2ALOX5
SCHEMBL1171782 0.84 ALOX5 (0.54) LTB4RLTB4R2ALOX5EGFRMAOB
SCHEMBL3988521 0.81 ALOX5 (0.62) FFAR1ALOX5
SCHEMBL1745247 0.80 FFAR1 (0.72) FFAR1FFAR4LTB4RLTB4R2AKR1B1
SCHEMBL1747136 0.80 FFAR1 (0.72) FFAR1FFAR4LTB4RLTB4R2AKR1B1
SCHEMBL5033197 0.80 FFAR1 (0.77) FFAR1FFAR4LTB4RLTB4R2ALOX5
SCHEMBL8358797 0.80 CYP2D6 (0.58) FFAR1LTB4RLTB4R2MAOB
SCHEMBL10695721 0.80 ALOX5 (0.80) FFAR1FFAR4LTB4RLTB4R2ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6046355-A TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS WARNER-LAMBERT COMPANY (US) 2000-04-04 US disclosed
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP disclosed
US-5834506-A TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS WARNER-LAMBERT COMPANY (US) 1998-11-10 US disclosed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed