Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 8/20 | 0.37 |
| ▸ | RAB9A | P51151 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1484237 | 0.93 | RAB9A (0.42) | ROCK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1497182 | 0.89 | RAB9A (0.41) | ROCK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1496998 | 0.88 | RAB9A (0.42) | ROCK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL10476428 | 0.86 | ROCK2 (0.38) | ROCK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1496982 | 0.85 | ATM (0.47) | ROCK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8002146 | 0.84 | RAB9A (0.45) | ROCK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1497123 | 0.84 | GAA (0.46) | ROCK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL2383085 | 0.83 | HDAC1 (0.47) | ROCK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1497023 | 0.81 | ALDH1A1 (0.41) | ROCK2NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7999000 | 0.81 | ALDH1A1 (0.42) | ROCK2NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009142321-A1 | NOVEL THIOPHENEDIAMINE DERIVATIVE HAVING UREA STRUCTURE | 参天製薬株式会社 (JP) | 2009-11-26 | — | — | WO | disclosed |