SCHEMBL7999660

SCHEMBL7999660

O=C(Cl)c1c(F)c(F)c2c(F)c(C(=O)Cl)c(F)c(F)c2c1F

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.37
CES1 P23141 1/20 0.37
ALDH1A1 P00352 2/20 0.33
ALOX15 P16050 1/20 0.31
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28352299 0.97 CES2 (0.41) CES2CES1ALDH1A1ALOX15HTT
SCHEMBL996758 0.88 CES2 (0.43) CES2CES1ALDH1A1ALOX15HTT
SCHEMBL1657 0.85 CES2 (0.48) CES2CES1ALDH1A1ALOX15HTT
SCHEMBL6538271 0.82 CES2 (0.46) CES2CES1ALDH1A1ALOX15HTT
SCHEMBL2295776 0.82 ALDH1A1 (0.39) CES2CES1ALDH1A1ALOX15
SCHEMBL10920457 0.80 CES2 (0.39) CES2CES1ALDH1A1ALOX15HTT
SCHEMBL19307720 0.79 CES2 (0.48) CES2CES1ALDH1A1ALOX15HTT
SCHEMBL10671409 0.78 ESR1 (0.39) CES2CES1ALDH1A1ALOX15HTT
SCHEMBL6740803 0.76 TAS1R3 (0.45) CES2CES1ALDH1A1ALOX15HTT
SCHEMBL9720476 0.76 CES2 (0.36) CES2CES1ALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6297351-B1 EXCELLENT IN ELECTRIC CHARACTERISTICS AND HEAT RESISTANCE, PRECURSOR FROM A DICARBOXYLIC ACID AND A BISAMINOPHENOL COMPOUND OR A DIAMINODIHYDROXY SUMITOMO BAKELITE COMPANY LIMITED (JP) 2001-10-02 US disclosed