SCHEMBL1657

SCHEMBL1657

O=C(Cl)c1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
HTT P42858 3/20 0.39
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
MAPK1 P28482 1/20 0.36
ALOX15 P16050 1/20 0.35
GAA P10253 1/20 0.34
PKM P14618 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
BRD4 O60885 1/20 0.31
TSHR P16473 2/20 0.31
RECQL P46063 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA4 P22748 1/20 0.31
HDAC3 O15379 1/20 0.30
HDAC11 Q96DB2 1/20 0.30
HDAC8 Q9BY41 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6538271 0.97 CES2 (0.46) CES2CES1HTTALDH1A1LMNA
SCHEMBL996758 0.97 CES2 (0.43) CES2CES1HTTALDH1A1LMNA
SCHEMBL19307720 0.93 CES2 (0.48) CES2CES1HTTALDH1A1LMNA
SCHEMBL2295776 0.90 ALDH1A1 (0.39) CES2CES1ALDH1A1ALOX15CA1
SCHEMBL28352299 0.89 CES2 (0.41) CES2CES1HTTALDH1A1LMNA
SCHEMBL10920457 0.88 CES2 (0.39) CES2CES1HTTALDH1A1ALOX15
SCHEMBL20529610 0.87 CES2 (0.50) CES2CES1HTTALDH1A1LMNA
SCHEMBL10671409 0.85 ESR1 (0.39) CES2CES1HTTALDH1A1ALOX15
SCHEMBL7999660 0.85 CES2 (0.37) CES2CES1HTTALDH1A1ALOX15
SCHEMBL7652879 0.84 TAS1R3 (0.42) CES2CES1HTTPKMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1073 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122080555-A Polytetrafluoroethylene nanofiller reinforced sealing gasket material and preparation method thereof 2026-05-26 CN claimed
US-20250230413-A1 METHODS AND SYSTEMS FOR THE CULTURE OF CELLS AT LIQUID-LIQUID INTERFACES UNIV LONDON QUEEN MARY (GB) 2025-07-17 US claimed
CN-119874563-A Cyclic biperoxides, synthesis method and application thereof in preparation of alkyl difunctional compounds 西安交通大学 2025-04-25 CN claimed
CN-118994908-B Modified plastic composite master batch and preparation method thereof 江苏汉光实业股份有限公司 2025-02-14 CN claimed
EP-4504903-A1 METHODS AND SYSTEMS FOR THE CULTURE OF CELLS AT LIQUID-LIQUID INTERFACES Queen Mary University of London (GB) 2025-02-12 EP claimed
CN-118834521-B Breathable polyurethane foaming sponge and preparation method thereof 扬州中天海绵有限公司 2025-02-07 CN claimed
CN-118772476-B High-strength base film for composite current collector and preparation method thereof 扬州博恒新能源材料科技有限公司 2024-11-29 CN claimed
CN-118994908-A Modified plastic composite master batch and preparation method thereof 江苏汉光实业股份有限公司 2024-11-22 CN claimed
CN-118955470-A Orbidisate Star synthesizing method 浙江国邦药业有限公司 2024-11-15 CN claimed
CN-118834521-A Breathable polyurethane foaming sponge and preparation method thereof 扬州中天海绵有限公司 2024-10-25 CN claimed
US-7247740-B2 Reacting perfluoroalkanesulfonic acid directly with dialkyl carbonate to give alkyl perfluoroalkanesulfonate optionally in the presence of a water or alcohol consuming reagent, and preparing an alkyl perfluoroalkanesulfonate with an alkylamine or alkylphosphine to prepare perfluoroalkanesulfonic acid MERCK PATENT GMBH (DE) 2007-07-24 US claimed
EP-1472217-B1 METHOD FOR PRODUCING PERFLUOROALKANE SULFONIC ACID ESTERS AND THE SALTS THEREOF MERCK PATENT GMBH (DE) 2007-01-24 EP claimed
JP-2005526012-A 2005-09-02 JP claimed
US-20050085655-A1 Reacting perfluoroalkanesulfonic acid directly with dialkyl carbonate to give alkyl perfluoroalkanesulfonate optionally in the presence of a water or alcohol consuming reagent, and preparing an alkyl perfluoroalkanesulfonate with an alkylamine or alkylphosphine to prepare perfluoroalkanesulfonic acid MERCK PATENT GMBH (DE) 2005-04-21 US claimed
EP-1472217-A2 METHOD FOR PRODUCING PERFLUOROALKANE SULFONIC ACID ESTERS AND THE SALTS THEREOF MERCK PATENT GmbH (DE) 2004-11-03 EP claimed
WO-2003053918-A2 METHOD FOR PRODUCING PERFLUOROALKANE SULFONIC ACID ESTERS AND THE SALTS THEREOF MERCK PATENT GMBH (DE) 2003-07-03 WO claimed
US-5776723-A Rapid detection of mycobacterium tuberculosis HEROLD CHRISTOPHER D (US) 1998-07-07 US claimed
WO-1997029374-A2 RAPID DETECTION OF MYCOBACTERIUM TUBERCULOSIS HEROLD CHRISTOPHER D (US) 1997-08-14 WO claimed
US-5059527-A Detection of endotoxins of gram negative bacteria WHITE DAVID C 1991-10-22 US claimed
US-4514500-A NEGATIVELY CHARGED FLUOROCARBONS FOR ADHESION OF SERUM PROTEINS GENERAL ELECTRIC COMPANY (US) 1985-04-30 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085655-A1 Reacting perfluoroalkanesulfonic acid directly with dialkyl carbonate to give alkyl perfluoroalkanesulfonate optionally in the presence of a water or alcohol consuming reagent, and preparing an alkyl perfluoroalkanesulfonate with an alkylamine or alkylphosphine to prepare perfluoroalkanesulfonic acid PFKFB2, PFKFB3, PHOSPHO1 CES2 167/4885CES1 504/4885HTT 4077/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.