Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387913 | 0.86 | CA1 (0.49) | SMN1; SMN2MAPTKMT2AALDH1A1LMNA | |
| SCHEMBL27167710 | 0.86 | CYP17A1 (0.51) | — | |
| SCHEMBL7996876 | 0.84 | KMT2A (0.49) | KDM4EKMT2AALDH1A1ADRB2ADRB1 | |
| SCHEMBL8405338 | 0.83 | POLB (0.54) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL3258334 | 0.80 | CA2 (0.50) | SMN1; SMN2KDM4EALDH1A1LMNATSHR | |
| SCHEMBL13249250 | 0.78 | CYP4A11 (0.57) | SMN1; SMN2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL5390555 | 0.78 | CYP17A1 (0.49) | SMN1; SMN2KDM4ENPC1RAB9APOLB | |
| SCHEMBL7609937 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTKDM4EKMT2AALDH1A1 | |
| SCHEMBL5755549 | 0.78 | HPGD (0.59) | SMN1; SMN2KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL12266895 | 0.77 | CYP1A2 (0.44) | MAPTKMT2AALDH1A1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288096-B1 | ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS | ASTRAZENECA AB (SE) | 2001-09-11 | — | — | US | disclosed |