Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000580 | 0.86 | SMN1; SMN2 (0.49) | POLBHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL7996876 | 0.85 | KMT2A (0.49) | CA1CA2ALDH1A1KMT2ACA9 | |
| SCHEMBL28396867 | 0.82 | AOC3 (0.54) | CA1CA2POLBCYP1A2CYP2D6 | |
| SCHEMBL27167710 | 0.81 | CYP17A1 (0.51) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL3258334 | 0.81 | CA2 (0.50) | CA1CA2ALDH1A1CA9TSHR | |
| SCHEMBL9585898 | 0.80 | ALDH1A1 (0.63) | CA1CA2CYP1A2TDP1ALDH1A1 | |
| SCHEMBL29622963 | 0.79 | AOC3 (0.67) | CA1CA2POLBCYP1A2CYP2C19 | |
| SCHEMBL29622962 | 0.79 | AOC3 (0.67) | CA1CA2POLBCYP1A2CYP2C19 | |
| SCHEMBL11039771 | 0.79 | KMT2A (0.50) | CA1CA2HPGDALDH1A1KMT2A | |
| SCHEMBL28890376 | 0.79 | CA2 (0.41) | CA1CA2ALDH1A1CA9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |