Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 3/20 | 0.48 |
| ▸ | BCAT1 | P54687 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009670 | 0.91 | TTR (0.49) | LMNATTRBCAT1NPC1RAB9A | |
| SCHEMBL8009573 | 0.84 | LMNA (0.45) | LMNATTRBCAT1NPC1RAB9A | |
| SCHEMBL8009574 | 0.84 | LMNA (0.45) | LMNATTRBCAT1NPC1RAB9A | |
| SCHEMBL8006393 | 0.81 | BCAT1 (0.50) | LMNATTRBCAT1NPC1RAB9A | |
| SCHEMBL8015805 | 0.77 | SLC22A12 (0.42) | LMNATTRBCAT1NPC1RAB9A | |
| SCHEMBL8000361 | 0.77 | BCAT1 (0.44) | LMNATTRBCAT1NPC1RAB9A | |
| SCHEMBL8012438 | 0.76 | BCAT1 (0.46) | LMNATTRBCAT1NPC1RAB9A | |
| SCHEMBL8010016 | 0.76 | MAPT (0.36) | LMNATTRBCAT1NPC1RAB9A | |
| SCHEMBL8012440 | 0.76 | BCAT1 (0.46) | LMNATTRBCAT1NPC1RAB9A | |
| SCHEMBL1222307 | 0.75 | TTR (0.78) | LMNATTRBCAT1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037361-A | GELATINASE, STROMELYSIN, COLLAGENASE, AND MATRILYSIN INHIBITORS; MULTIPLE SCLEROSIS TREATMENT; BRAIN AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-03-14 | — | — | US | claimed |
| US-6037361-A | GELATINASE, STROMELYSIN, COLLAGENASE, AND MATRILYSIN INHIBITORS; MULTIPLE SCLEROSIS TREATMENT; BRAIN AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-03-14 | — | — | US | disclosed |