Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.42 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009670 | 0.86 | TTR (0.49) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL8010016 | 0.82 | MAPT (0.36) | ALDH1A1MEN1CYP2C9HPGDKMT2A | |
| SCHEMBL8000595 | 0.77 | LMNA (0.48) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL8000361 | 0.73 | BCAT1 (0.44) | ALDH1A1HPGDLMNATTRRAB9A | |
| SCHEMBL8009573 | 0.72 | LMNA (0.45) | MEN1KMT2ALMNATTRRAB9A | |
| SCHEMBL8009574 | 0.72 | LMNA (0.45) | MEN1KMT2ALMNATTRRAB9A | |
| SCHEMBL14540848 | 0.71 | NPC1 (0.59) | SLC22A12EYA3HTTALDH1A1MEN1 | |
| SCHEMBL5308204 | 0.70 | MAPT (0.64) | HTTALDH1A1MEN1CYP1A2CYP2C9 | |
| SCHEMBL21313809 | 0.69 | TTR (0.71) | ALDH1A1MEN1CYP2C9HPGDKMT2A | |
| SCHEMBL8006393 | 0.69 | BCAT1 (0.50) | ALDH1A1MEN1HPGDKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037361-A | GELATINASE, STROMELYSIN, COLLAGENASE, AND MATRILYSIN INHIBITORS; MULTIPLE SCLEROSIS TREATMENT; BRAIN AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-03-14 | — | — | US | claimed |
| US-6037361-A | GELATINASE, STROMELYSIN, COLLAGENASE, AND MATRILYSIN INHIBITORS; MULTIPLE SCLEROSIS TREATMENT; BRAIN AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-03-14 | — | — | US | disclosed |