Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009670 | 0.85 | TTR (0.49) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8015805 | 0.82 | SLC22A12 (0.42) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL23693530 | 0.79 | TTR (0.53) | MAPTNPC1ADORA2ACASP1RAB9A | |
| SCHEMBL8000595 | 0.76 | LMNA (0.48) | MAPTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8000361 | 0.74 | BCAT1 (0.44) | MAPTNPC1RAB9AIDO1LMNA | |
| SCHEMBL29886929 | 0.73 | TTR (0.56) | MAPTNPC1ADORA2ACASP1RAB9A | |
| SCHEMBL23693577 | 0.73 | TTR (0.56) | MAPTNPC1ADORA2ACASP1RAB9A | |
| SCHEMBL23693559 | 0.71 | TSHR (0.49) | MAPTCASP1SMN1; SMN2IDO1KCNH2 | |
| SCHEMBL8954362 | 0.71 | TTR (0.57) | NPC1RAB9ATTRALDH1A1HPGD | |
| SCHEMBL8009574 | 0.71 | LMNA (0.45) | NPC1RAB9AIDO1LMNATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037361-A | GELATINASE, STROMELYSIN, COLLAGENASE, AND MATRILYSIN INHIBITORS; MULTIPLE SCLEROSIS TREATMENT; BRAIN AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-03-14 | — | — | US | claimed |
| US-6037361-A | GELATINASE, STROMELYSIN, COLLAGENASE, AND MATRILYSIN INHIBITORS; MULTIPLE SCLEROSIS TREATMENT; BRAIN AND NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-03-14 | — | — | US | disclosed |