Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | HTR2B | P41595 | 3/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735049 | 0.81 | HTR1A (0.63) | HTR1AHTR2BMTNR1AMTNR1BHTR2A | |
| SCHEMBL14527148 | 0.81 | HTR1A (0.63) | HTR1AHTR2BMTNR1AHTR2AHTR2C | |
| SCHEMBL7997808 | 0.75 | HTR2A (0.62) | HTR1AHTR2BMTNR1AMTNR1BHTR2A | |
| SCHEMBL1196112 | 0.75 | HTR1A (0.75) | HTR1AHTR2BMTNR1AMTNR1BHTR2A | |
| SCHEMBL699832 | 0.75 | HTR2A (0.73) | HTR1AHTR2AHTR2CGPR84 | |
| SCHEMBL7995785 | 0.74 | HTR2B (0.60) | HTR1AHTR2BMTNR1AMTNR1BHTR2A | |
| SCHEMBL1196782 | 0.74 | HTR2B (0.61) | HTR1AHTR2BMTNR1AMTNR1BHTR2A | |
| SCHEMBL1196780 | 0.74 | HTR2B (0.61) | HTR1AHTR2BMTNR1AMTNR1BHTR2A | |
| SCHEMBL2534666 | 0.74 | HTR1A (0.72) | HTR1AHTR2BMTNR1AMTNR1BHTR2A | |
| SCHEMBL23259357 | 0.73 | GPR84 (0.65) | HTR1AHTR2BHTR2AHTR2CGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001040183-A1 | 1-AMINOALKYL-1H-INDOLES FOR TREATING GLAUCOMA | ALCON UNIVERSAL LTD. (CH) | 2001-06-07 | — | — | WO | disclosed |