Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 4/20 | 0.61 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1196782 | 1.00 | HTR2B (0.61) | HTR2BMTNR1AMTNR1BHTR1ACYP3A4 | |
| SCHEMBL19068552 | 0.90 | MTNR1A (0.57) | HTR2BMTNR1AMTNR1BHTR1ACYP3A4 | |
| SCHEMBL16645257 | 0.90 | MTNR1A (0.57) | HTR2BMTNR1AMTNR1BHTR1ACYP3A4 | |
| SCHEMBL1196209 | 0.87 | GPR84 (0.47) | HTR2BMTNR1AMTNR1BHTR1ACYP3A4 | |
| SCHEMBL1196208 | 0.87 | GPR84 (0.47) | HTR2BMTNR1AMTNR1BHTR1ACYP3A4 | |
| SCHEMBL16645248 | 0.84 | MTNR1A (0.48) | HTR2BMTNR1AMTNR1BHTR1ACYP3A4 | |
| SCHEMBL19068566 | 0.84 | MTNR1A (0.48) | HTR2BMTNR1AMTNR1BHTR1ACYP3A4 | |
| SCHEMBL14527148 | 0.83 | HTR1A (0.63) | HTR2BMTNR1AHTR1ACYP1A2CYP2D6 | |
| SCHEMBL5165399 | 0.81 | HTR2A (0.64) | HTR2BMTNR1AMTNR1BHTR1ACYP3A4 | |
| SCHEMBL5165731 | 0.81 | HTR2A (0.53) | HTR2BHTR1ACYP3A4KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110027226-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) | 4SC AG (DE) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110027226-A1 | INDOLOPYRIDINES AS INHIBITORS OF THE KINESIN SPINDLE PROTEIN (EG5) | KIF5A, KIF5C, KIF5B | HTR2B 3838/4885MTNR1A 3754/4885MTNR1B 4032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.