Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998940 | 0.87 | NFE2L2 (0.64) | NFE2L2RELAFBP1 | |
| SCHEMBL8002658 | 0.87 | NFE2L2 (0.45) | NFE2L2RELAFBP1 | |
| SCHEMBL8002291 | 0.84 | NFE2L2 (0.60) | NFE2L2RELAFBP1 | |
| SCHEMBL7988658 | 0.79 | PPARG (0.44) | PPARGLMNAALDH1A1MAOBMEN1 | |
| SCHEMBL7988653 | 0.78 | MAOB (0.41) | NFE2L2PPARGLMNAALDH1A1MAOB | |
| SCHEMBL8001632 | 0.78 | MAPT (0.48) | NFE2L2PPARGLMNAMAOBMMP1 | |
| SCHEMBL7998337 | 0.77 | NFE2L2 (0.62) | NFE2L2RELAFBP1 | |
| SCHEMBL8002290 | 0.75 | MAOB (0.47) | NFE2L2MAOBMMP1MMP2MMP9 | |
| SCHEMBL1122564 | 0.74 | NFE2L2 (0.56) | NFE2L2PPARGLMNAALDH1A1RELA | |
| SCHEMBL1122565 | 0.74 | NFE2L2 (0.56) | NFE2L2PPARGLMNAALDH1A1RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120783-A1 | HIGH AFFINITY INHIBITORS OF HEPATITIS C VIRUS NS3/4A PROTEASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-10-01 | — | — | WO | disclosed |