Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 6/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8002652 | 0.89 | L3MBTL1 (0.43) | MAOBPTGES2FBP1NFE2L2MAPT | |
| SCHEMBL7998811 | 0.87 | LMNA (0.43) | PTGES2FBP1NFE2L2MAPTCA1 | |
| SCHEMBL7989468 | 0.83 | NFE2L2 (0.40) | MAOBPTGES2NFE2L2MAPTSMN1; SMN2 | |
| SCHEMBL8002292 | 0.82 | LMNA (0.40) | PTGES2FBP1NFE2L2MAPTCA1 | |
| SCHEMBL8001632 | 0.78 | MAPT (0.48) | MAOBFBP1NFE2L2MAPTMMP1 | |
| SCHEMBL7988653 | 0.78 | MAOB (0.41) | MAOBNFE2L2MAPTKMT2A | |
| SCHEMBL7998895 | 0.77 | NFE2L2 (0.41) | PTGES2FBP1NFE2L2 | |
| SCHEMBL8001633 | 0.75 | NFE2L2 (0.50) | MAOBFBP1NFE2L2MAPTTP53 | |
| SCHEMBL7988652 | 0.74 | PPARG (0.44) | MAOBMAPTKMT2A | |
| SCHEMBL5488840 | 0.72 | PTGES2 (0.41) | MAOBPTGES2FBP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120783-A1 | HIGH AFFINITY INHIBITORS OF HEPATITIS C VIRUS NS3/4A PROTEASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-10-01 | — | — | WO | disclosed |