Tyramine

Tyramine

SCHEMBL8003312

Clc1nc(Cl)nc(Cl)n1.NCCc1ccc(O)cc1.NCc1ccccc1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 5/20 0.56
KDM4E B2RXH2 1/20 0.56
ALDH1A1 P00352 1/20 0.56
HTR1A P08908 1/20 0.56
ADRA2A P08913 1/20 0.56
SLC6A2 P23975 1/20 0.56
CYP2C19 P33261 1/20 0.56
HTR3A P46098 1/20 0.56
BACE1 P56817 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
BLM P54132 1/20 0.55
KMT2A Q03164 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
HTR2A P28223 2/20 0.50
LOXL2 Q9Y4K0 2/20 0.50
CYP2A6 P11509 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
ABAT P80404 1/20 0.50
DRD2 P14416 1/20 0.46
DRD1 P21728 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tyramine SCHEMBL8006818 0.95 TAAR1 (0.62) TAAR1KDM4EALDH1A1HTR1AADRA2A
Tyramine SCHEMBL8001418 0.94 TAAR1 (0.64) TAAR1KDM4EALDH1A1HTR1AADRA2A
Tyramine SCHEMBL8002976 0.88 TAAR1 (0.72) TAAR1KDM4EALDH1A1HTR1AADRA2A
SCHEMBL7999980 0.85 ABAT (0.70) TAAR1KDM4EALDH1A1HTR1AADRA2A
Tyramine SCHEMBL7991337 0.83 ALDH1A1 (0.64) TAAR1KDM4EALDH1A1HTR1AADRA2A
Tyramine SCHEMBL6137697 0.83 TAAR1 (0.82) TAAR1KDM4EALDH1A1HTR1AADRA2A
Tyramine SCHEMBL7999818 0.79 ALDH1A1 (0.58) TAAR1KDM4EALDH1A1HTR1AADRA2A
Tyramine SCHEMBL10006913 0.79 TAAR1 (0.82) TAAR1KDM4EALDH1A1HTR1AADRA2A
Tyramine SCHEMBL28645404 0.79 TAAR1 (0.90) TAAR1KDM4EALDH1A1HTR1AADRA2A
SCHEMBL7991430 0.79 ABAT (0.47) TAAR1ALDH1A1KMT2ALOXL2ABAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6117996-A COMPLEXING; SEPARATION; PURIFICATION OF PROTEINS NOVO NORDISK A/S (DK) 2000-09-12 US disclosed