Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011719 | 0.88 | HMGCR (0.51) | HMGCRKMT2AMEN1NPSR1LMNA | |
| SCHEMBL7119145 | 0.84 | HMGCR (0.46) | HMGCRKMT2AMEN1NPSR1LMNA | |
| SCHEMBL8015604 | 0.81 | GAA (0.48) | HMGCRKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL8143057 | 0.80 | KMT2A (0.45) | KMT2AMEN1NPSR1LMNAALDH1A1 | |
| SCHEMBL7124088 | 0.79 | HMGCR (0.47) | HMGCRKMT2AMEN1NPSR1LMNA | |
| SCHEMBL8766613 | 0.78 | HMGCR (0.49) | HMGCRKMT2AMEN1NPSR1MAPT | |
| SCHEMBL8142160 | 0.77 | LMNA (0.46) | KMT2AMEN1NPSR1LMNAALDH1A1 | |
| SCHEMBL5367565 | 0.75 | KMT2A (0.50) | KMT2AMEN1NPSR1LMNAALDH1A1 | |
| SCHEMBL8014329 | 0.75 | MEN1 (0.51) | HMGCRKMT2AMEN1NPSR1LMNA | |
| SCHEMBL8144918 | 0.75 | NR1H4 (0.43) | KMT2AMEN1NPSR1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835116-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1998-04-15 | — | — | EP | claimed |
| WO-1997002037-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1997-01-23 | — | — | WO | claimed |
| US-6060464-A | Compounds and pharmaceutical compositions containing them | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-05-09 | — | — | US | disclosed |
| EP-0835116-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997002037-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYMPHAR S.A. (CH) | 1997-01-23 | — | — | WO | disclosed |