Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 11/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8104657 | 0.99 | AOC3 (0.50) | AOC3SMN1; SMN2SUCNR1 | |
| SCHEMBL8004575 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2SUCNR1 | |
| Hydrochloric Acid SCHEMBL8097516 | 0.82 | SMN1; SMN2 (0.45) | SMN1; SMN2SUCNR1 | |
| SCHEMBL8185434 | 0.81 | SLC9A1 (0.52) | SMN1; SMN2 | |
| SCHEMBL7995147 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2SUCNR1 | |
| Hydrochloric Acid SCHEMBL7995081 | 0.77 | PTGDR2 (0.42) | AOC3SMN1; SMN2 | |
| SCHEMBL8006634 | 0.76 | PPARG (0.38) | AOC3SUCNR1 | |
| Hydrochloric Acid SCHEMBL8611682 | 0.75 | PPARG (0.38) | AOC3SUCNR1 | |
| SCHEMBL8183089 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2 | |
| SCHEMBL27436629 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748795-B1 | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | HOECHST AG (DE) | 2000-08-23 | — | — | EP | disclosed |
| US-6022899-A | EFFECTIVE INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-02-08 | — | — | US | disclosed |
| US-5753710-A | INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-19 | — | — | US | disclosed |
| EP-0748795-A2 | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-18 | — | — | EP | disclosed |