Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | TPMT | P51580 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995380 | 0.86 | CA1 (0.45) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8818855 | 0.86 | CA12 (0.53) | MAPTMEN1KMT2AALDH1A1PLAU | |
| SCHEMBL7995531 | 0.79 | CA1 (0.50) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8444679 | 0.79 | ALDH1A1 (0.54) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8005080 | 0.78 | KMT2A (0.51) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL30045029 | 0.78 | TPMT (0.61) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2159357 | 0.78 | TPMT (0.61) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2410383 | 0.78 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1PTGER1TPMT | |
| SCHEMBL6252554 | 0.78 | ALDH1A1 (0.51) | MAPTMEN1KMT2AALDH1A1SRD5A2 | |
| SCHEMBL8815952 | 0.77 | S1PR4 (0.43) | MAPTMEN1KMT2AALDH1A1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017917-A | Guanidine derivatives | FUJISAWA PHARAMCEUTICAL CO., LTD. (JP) | 2000-01-25 | — | — | US | disclosed |
| EP-0876338-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025310-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-17 | — | — | WO | disclosed |