SCHEMBL80058

SCHEMBL80058

Nc1nc2c(ncn2[C@@H]2O[C@@H](CO[P@@](=O)(O)OP(=O)(O)O)[C@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.82

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 1/20 0.82
NT5E P21589 1/20 0.77
KRAS P01116 5/20 0.74
FUT5 Q11128 1/20 0.73
P2RX3 P56373 2/20 0.69
P2RY6 Q15077 2/20 0.69
P2RY2 P41231 1/20 0.69
P2RY4 P51582 1/20 0.69
ENPP1 P22413 2/20 0.67
P2RY1 P47900 2/20 0.67
P2RY12 Q9H244 1/20 0.67
IMPDH2 P12268 5/20 0.66
P2RX1 P51575 1/20 0.66
P2RY11 Q96G91 1/20 0.66
P2RX4 Q99571 1/20 0.66
IMPDH1 P20839 1/20 0.66
DCPS Q96C86 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17072523 1.00 TGM2 (0.82) TGM2NT5EKRASFUT5P2RX3
SCHEMBL37405 1.00 TGM2 (0.82) TGM2NT5EKRASFUT5P2RX3
SCHEMBL101367 1.00 TGM2 (0.82) TGM2NT5EKRASFUT5P2RX3
SCHEMBL13210265 1.00 TGM2 (0.82) TGM2NT5EKRASFUT5P2RX3
SCHEMBL18775378 1.00 TGM2 (0.82) TGM2NT5EKRASFUT5P2RX3
SCHEMBL23969756 1.00 TGM2 (0.82) TGM2NT5EKRASFUT5P2RX3
Triphosphate SCHEMBL28597197 1.00 TGM2 (0.82) TGM2NT5EKRASFUT5P2RX3
SCHEMBL18785111 1.00 TGM2 (0.82) TGM2NT5EKRASFUT5P2RX3
Gtp SCHEMBL5809658 0.99 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3
SCHEMBL1304258 0.99 TGM2 (0.81) TGM2NT5EKRASFUT5P2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 231 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117618654-A Antibacterial angiogenesis-promoting nylon6 material and preparation method thereof 中维化纤股份有限公司 2024-03-01 CN claimed
WO-2020008209-A1 TRIPHOSPHORYLATION REACTION THE UNIVERSITY OF DURHAM (GB) 2020-01-09 WO claimed
WO-2001077366-A1 POSITIVE SELECTION METHOD, COMPOUNDS, HOST CELLS AND USES THEREOF CUBIST PHARMACEUTICALS, INC. (US) 2001-10-18 WO claimed
EP-0090417-B1 PROCESS FOR PRODUCING 3'-DEOXYGUANOSINE Yamasa Shoyu Kabushiki Kaisha (JP) 1989-03-01 EP claimed
US-4594321-A Reacting guanine derivative with phosphate YAMASA SHOYU KABUSHIKI KAISHA (JP) 1986-06-10 US claimed
US-4594320-A Reacting guanine derivative with phosphate compound YAMASA SHOYU KABUSHIKI KAISHA (JP) 1986-06-10 US claimed
US-4577012-A ABSORPTION ON ACTIVATED CARBON, ELUTION WITH ALKALI HYDROXIDE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-03-18 US claimed
EP-0090417-A2 Process for producing 3'-deoxyguanosine Yamasa Shoyu Kabushiki Kaisha (JP) 1983-10-05 EP claimed
JP-4169198-A None JP disclosed
US-20260091009-A1 ROLES OF MODULATORS OF INTERSECTIN-CDC42 SIGNALING IN ALZHEIMER'S DISEASE Lu, Qun (US) 2026-04-02 US disclosed
US-20250388595-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2B, COMPOSITIONS AND METHODS DENALI THERAPEUTICS INC (US) 2025-12-25 US disclosed
US-20250388620-A1 EFFICIENT METHOD FOR MAKING HIGHLY PURIFIED 5’- CAPPED OLIGONUCLEOTIDES TRILINK BIOTECHNOLOGIES, LLC (US) 2025-12-25 US disclosed
US-20250215043-A1 RNA CAP ANALOGS AND METHODS OF USE MEDICI THERAPEUTICS, INC. 2025-07-03 US disclosed
EP-4577553-A2 EFFICIENT METHOD FOR MAKING HIGHLY PURIFIED 5'-CAPPED OLIGONUCLEOTIDES TriLink BioTechnologies, LLC (US) 2025-07-02 EP disclosed
EP-0189755-A1 Pharmaceutical composition F. HOFFMANN-LA ROCHE AG (CH) 1986-08-06 EP disclosed
US-4594320-A Reacting guanine derivative with phosphate compound YAMASA SHOYU KABUSHIKI KAISHA (JP) 1986-06-10 US disclosed
US-4594321-A Reacting guanine derivative with phosphate YAMASA SHOYU KABUSHIKI KAISHA (JP) 1986-06-10 US disclosed
US-4577012-A ABSORPTION ON ACTIVATED CARBON, ELUTION WITH ALKALI HYDROXIDE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-03-18 US disclosed
EP-0090417-A2 Process for producing 3'-deoxyguanosine Yamasa Shoyu Kabushiki Kaisha (JP) 1983-10-05 EP disclosed
US-4297347-A 3'-DI- OR -TRIPHOSPHATES OF GUANOSINE, URIDINE, AND CYTIDINE KATSUNUMA NOBUHIKO 1981-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388620-A1 EFFICIENT METHOD FOR MAKING HIGHLY PURIFIED 5’- CAPPED OLIGONUCLEOTIDES RNGTT, NSUN2, RNMT TGM2 3990/4885NT5E 327/4885KRAS 1709/4885
US-20250215043-A1 RNA CAP ANALOGS AND METHODS OF USE RNGTT, RNMT, NSUN2 TGM2 3831/4885NT5E 310/4885KRAS 1986/4885
US-20260091009-A1 ROLES OF MODULATORS OF INTERSECTIN-CDC42 SIGNALING IN ALZHEIMER'S DISEASE CDC42, GAP43, HASPIN TGM2 3730/4885NT5E 3988/4885KRAS 337/4885
US-20250388595-A1 MODULATORS OF EUKARYOTIC INITIATION FACTOR 2B, COMPOSITIONS AND METHODS EIF2B1, EIF4EBP1, EIF2B3 TGM2 2685/4885NT5E 3766/4885KRAS 1322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.