Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018649 | 0.82 | MEN1 (0.39) | POLBTDP1APEX1HTTSMN1; SMN2 | |
| SCHEMBL11294405 | 0.79 | TDP1 (0.54) | POLBTDP1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL691683 | 0.77 | TDP1 (0.40) | POLBTDP1APEX1HTTSMN1; SMN2 | |
| SCHEMBL8043107 | 0.73 | THRB (0.57) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL7430087 | 0.73 | TDP1 (0.56) | POLBTDP1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL7622862 | 0.72 | KDM4E (0.37) | POLBTDP1APEX1HTTSMN1; SMN2 | |
| SCHEMBL7436439 | 0.72 | TDP1 (0.55) | TDP1SMN1; SMN2MAPTNPC1GAA | |
| SCHEMBL7182348 | 0.71 | RECQL (0.55) | SMN1; SMN2MAPTNPC1GAARAB9A | |
| SCHEMBL28058450 | 0.71 | RAB9A (0.53) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL28225095 | 0.71 | POLB (0.48) | POLBTDP1APEX1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000034804-A1 | HIGH REFRACTIVE INDEX HYDROGEL COMPOSITIONS FOR OPHTHALMIC IMPLANTS | BAUSCH & LOMB SURGICAL, INC. (US) | 2000-06-15 | — | — | WO | disclosed |