Toluene

Toluene

SCHEMBL8006523

Cc1ccccc1.O=[N+]([O-])c1cc(C(F)(F)F)ccc1Cl

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.54
ALDH1A1 P00352 3/20 0.51
CYP3A4 P08684 2/20 0.51
TDP1 Q9NUW8 2/20 0.51
HPGD P15428 1/20 0.51
ALOX15 P16050 1/20 0.51
TSHR P16473 1/20 0.51
HIF1A Q16665 1/20 0.51
TXNRD1 Q16881 1/20 0.51
TXNRD3 Q86VQ6 1/20 0.51
TXNRD2 Q9NNW7 1/20 0.51
LMNA P02545 4/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
MASP2 O00187 1/20 0.48
F2 P00734 1/20 0.48
MAPT P10636 4/20 0.47
VCAM1 P19320 1/20 0.47
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL140068 0.88 ALDH1A1 (0.65) MAPK1ALDH1A1CYP3A4TDP1HPGD
Nitric Acid SCHEMBL11801208 0.83 ALDH1A1 (0.59) MAPK1ALDH1A1CYP3A4TDP1HPGD
Nitric Acid SCHEMBL11801207 0.83 ALDH1A1 (0.59) MAPK1ALDH1A1CYP3A4TDP1HPGD
SCHEMBL7218755 0.78 TDP1 (0.55) MAPK1ALDH1A1CYP3A4TDP1HPGD
Toluene SCHEMBL27576042 0.76 HSD17B10 (0.53) MAPK1ALDH1A1TDP1HPGDTSHR
SCHEMBL8569064 0.76 ALDH1A1 (0.53) MAPK1ALDH1A1CYP3A4TDP1HPGD
SCHEMBL11858422 0.76 VCAM1 (0.51) ALDH1A1LMNASMN1; SMN2MAPTVCAM1
SCHEMBL1104675 0.75 VCAM1 (0.51) MAPK1ALDH1A1CYP3A4TDP1HPGD
SCHEMBL4416018 0.75 MAPK1 (0.57) MAPK1ALDH1A1CYP3A4TDP1HPGD
SCHEMBL29446908 0.75 TDP1 (0.59) MAPK1ALDH1A1CYP3A4TDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000069800-A2 PROCESS FOR PREPARING KETONES OR ALDEHYDES AVENTIS CROPSCIENCE S.A. (FR) 2000-11-23 WO disclosed