Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.54 |
| ▸ | MTOR | P42345 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dioxethedrin SCHEMBL249560 | 0.80 | ADRB2 (0.58) | TDP1KDM4EMAPTADRB2ADRB1 | |
| SCHEMBL21566671 | 0.80 | MAPT (0.50) | TDP1KDM4EMAPTADRB2ADRB1 | |
| Dioxethedrin SCHEMBL365011 | 0.79 | KDM4E (0.57) | TDP1KDM4EMAPTADRB2ADRB1 | |
| SCHEMBL28141655 | 0.78 | ADRB2 (0.47) | TDP1KDM4EMAPTADRB2ADRB1 | |
| Bromide SCHEMBL11805158 | 0.78 | TDP1 (0.52) | TDP1KDM4EMAPTADRB2ADRB1 | |
| SCHEMBL19604903 | 0.78 | ESR1 (0.50) | TDP1KDM4EMAPTADRB2ADRB1 | |
| SCHEMBL683547 | 0.74 | HSD17B10 (0.69) | TDP1KDM4EMAPTADRB2ADRB1 | |
| SCHEMBL10058634 | 0.73 | L3MBTL1 (0.42) | ADRB2ADRB1MAPK1KMT2AADRB3 | |
| SCHEMBL10058162 | 0.73 | L3MBTL1 (0.42) | ADRB2ADRB1MAPK1KMT2AADRB3 | |
| SCHEMBL12849015 | 0.73 | ALDH1A1 (0.54) | MAPK1KMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120799-A2 | METHODS OF TREATING FIBROTIC DISORDERS | PALOMA PHARMACEUTICALS, INC. (US) | 2009-10-01 | — | — | WO | disclosed |