Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 7/20 | 0.50 |
| ▸ | PTGER2 | P43116 | 7/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28185004 | 0.86 | PTGER3 (0.58) | PTGER3PTGER2PTGER4PTGER1CA1 | |
| SCHEMBL1717109 | 0.86 | PTGER3 (0.67) | PTGER3PTGER2PTGER4PTGER1CA1 | |
| SCHEMBL30679 | 0.85 | GABRA1 (0.47) | NFKB1GABRA1GABRB2KDM4EKMT2A | |
| Methane SCHEMBL28621463 | 0.83 | GABRA1 (0.45) | NFKB1GABRA1GABRB2KDM4EKMT2A | |
| Charcoal, Activated SCHEMBL9723291 | 0.83 | GABRA1 (0.45) | NFKB1GABRA1GABRB2KDM4EKMT2A | |
| Phenol SCHEMBL27962166 | 0.82 | GABRA1 (0.47) | CA1CA2CA4GABRA1GABRB2 | |
| Sulfuric Acid SCHEMBL4875624 | 0.82 | POLB (0.45) | NFKB1GABRA1GABRB2KDM4ESMN1; SMN2 | |
| Maleic Acid SCHEMBL11627287 | 0.81 | CA1 (0.52) | PTGER3PTGER2PTGER4CA1CA2 | |
| Fumaric Acid SCHEMBL11627288 | 0.81 | CA1 (0.52) | PTGER3PTGER2PTGER4CA1CA2 | |
| 2-Allylphenol SCHEMBL11378333 | 0.81 | AKR1B1 (0.50) | PTGER3PTGER2PTGER4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665468-B1 | Staining inhibitor for photopolymerizable compositions containing a tetrazole | MACDERMID IMAGING TECHNOLOGY (US) | 2000-04-19 | — | — | EP | disclosed |
| EP-0665468-A1 | Staining inhibitor for photopolymerizable compositions containing a tetrazole | HERCULES INCORPORATED (US) | 1995-08-02 | — | — | EP | disclosed |