Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 2/20 | 0.48 |
| ▸ | WEE1 | P30291 | 13/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8006796 | 0.81 | CHEK1 (0.51) | WEE1CHEK1 | |
| SCHEMBL28709463 | 0.81 | TDP2 (0.64) | TDP2BRAFWEE1CHEK1 | |
| SCHEMBL29652041 | 0.81 | TDP2 (0.64) | TDP2BRAFWEE1CHEK1 | |
| SCHEMBL8000252 | 0.80 | MAPT (0.48) | CHEK1 | |
| SCHEMBL10911536 | 0.72 | GSK3B (0.41) | WEE1CHEK1 | |
| SCHEMBL8757366 | 0.70 | WEE1 (0.50) | TDP2BRAFWEE1CHEK1 | |
| SCHEMBL9980565 | 0.70 | KDM4E (0.43) | WEE1CHEK1 | |
| SCHEMBL8690765 | 0.70 | WEE1 (0.50) | WEE1CHEK1 | |
| SCHEMBL27494083 | 0.69 | PARP1 (0.42) | WEE1CHEK1 | |
| SCHEMBL27678098 | 0.69 | KDM4E (0.39) | WEE1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000021910-A2 | 1,2-DISUBSTITUTED CYCLOPROPANES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-04-20 | — | — | WO | disclosed |